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ea0026p132 | Growth factors | ECE2011

Bone turnover and mineral density in thalassemia: relationships with gh secretory status and circulating somatomedins

Danesi Leila , Cattaneo Agnese , Scacchi Massimo , Sciortino Giovanna , Vitale Giovanni , Domenica Cappellini Maria , Arvigo Marica , Ferone Diego , Minuto Francesco , Cavagnini Francesco

Introduction: Previous data from our group suggested a role for the GH/IGF1 axis in the pathophysiology of osteoporosis in thalassemia (Clin Endocrinol 69:202, 2008). The present study was aimed at evaluating the relationships between circulating IGFs and bone metabolism and density in a very large series of adult thalassemic patients.Study design: One hundred and thirty-nine patients affected by thalassemia major (mean age 32.3±7.87 years) underwen...

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ea0032p865 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Effects of somatostatin analogues on muscle sympathetic nerve activity in acromegaly

Carzaniga Chiara , Seravalle Gino , Attanasio Roberto , Grassi Guido , Cozzi Renato , Maria Fatti Letizia , Montini Marcella , Vitale Giovanni , Sciortino Giovanna , Damanti Sarah , Scacchi Massimo , Mancia Giuseppe , Cavagnini Francesco , Persani Luca

Introduction: While searching for mechanisms contributing to the increased mortality of acromegaly, we have previously described an unexpected sympathoinhibition in newly diagnosed patients (Seravalle et al., Clin Endocrinol 77:262, 2012) and interpreted this finding as an adaptive phenomenon. It has also been shown that centrally administered somatostatin (SS) inhibits peripheral sympathetic outflow in rodents (Rettig et al., Am J Physiol 257:R588, 1989). Ba...

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Endocrine Abstracts

Bone turnover and mineral density in thalassemia: relationships with gh secretory status and circulating somatomedins

Effects of somatostatin analogues on muscle sympathetic nerve activity in acromegaly

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